反应详情

Trifluoroacetic acid (5 mL) was added to a solution of tert-butyl 4-(benzo[d]thiazole-2-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate (example 106, step a) (0.83 g) in DCM (15 mL) and the resulting mixture was stirred for 25 minutes. The solvent was evaporated in vacuo. The residue was dissolved in DCM:methanol (1:1) (5 mL) and applied to a SCX cartridge pre-wetted with DCM:methanol (1:1). The cartridge was washed with methanol (60 mL) and eluted with 2M ammonia in methanol solution (40 mL). The eluent was evaporated in vacuo to give the subtitled compound as a colourless oil. Yield 0.57 g.

1. customThe solvent was evaporated in vacuo
2. dissolutionThe residue was dissolved in DCM:methanol (1:1) (5 mL)
3. washThe cartridge was washed with methanol (60 mL)
4. washeluted with 2M ammonia in methanol solution (40 mL)
5. customThe eluent was evaporated in vacuo