反应详情

温度

70 °C

A mixture of 6-benzyl-1-oxa-6-azaspiro[2.5]octane (2 g) and 2-methylprop-2-en-1-amine HCl (2 g) and Hunig's Base (3.44 mL) in ethanol (30 mL) was heated at 70° C. for 18 hours. The mixture was cooled to room temperature and the solvent evaporated under reduced pressure. The residue was partitioned between DCM and brine, the aqueous layer was re-extracted with fresh DCM and the combined organics dried over sodium sulphate, filtered and the solvent evaporated under reduced pressure to afford the subtitled compound. Yield 2.70 g.

1. temperatureThe mixture was cooled to room temperature
2. customthe solvent evaporated under reduced pressure
3. customThe residue was partitioned between DCM and brine
4. extractionthe aqueous layer was re-extracted with fresh DCM
5. dry with materialthe combined organics dried over sodium sulphate
6. filtrationfiltered
7. customthe solvent evaporated under reduced pressure