反应详情

To a solution of N,N-dimethyl hydrazine (0.55 g) in ether (46 mL) was added 4-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoyl chloride (2.00 g) in small portions at 0° C. After 50 min at this temperature, water was added and the pH was adjusted to 7 by addition of NaOH (2 M). The organic layer was separated and the aqueous layer was extracted with ether. Combined organic layers were washed with NaHCO3 solution, dried over Na2SO4 and evaporated to give the title compound (1.50 g, 71%).

1. customThe organic layer was separated
2. extractionthe aqueous layer was extracted with ether
3. washCombined organic layers were washed with NaHCO3 solution
4. dry with materialdried over Na2SO4
5. customevaporated