HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Iodosuccinimide → 5-Iodo-6-(trifluoromethyl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Reactant | 2-Amino-6-(trifluoromethyl)pyridine | HCID 821024 | — |
| Product | 5-Iodo-6-(trifluoromethyl)pyridin-2-amine | HCID 58073065 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP1 starting from 4.8 g (30 mmol) 6-trifluoromethyl-pyridin-2-ylamine and 6.7 g (30 mmol) NIS. Yield after precipitation from the reaction mixture and isolation of additional product from the mother liquid by chromatography in silica gel: 5.73 g (67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08633183B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-e63083d2adb44062b01f7509973f862e |
| Source note | uspto-grants-2014_01 |