Potassium Carbonate → HCID 58072731, compound

HRID 471405Notes

Reaction equation

HRID 471405 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[N:8]=[C:7]([NH2:9])[CH:6]=[CH:5][C:4]=1[C:10]#[C:11][Si](C)(C)C.C([O-])([O-])=O.[K+].[K+]>CO>[C:10]([C:4]1[CH:5]=[CH:6][C:7]([NH2:9])=[N:8][C:3]=1[C:2]([F:1])([F:17])[F:16])#[CH:11]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 58072964HCID 58072964, compound

Product 1

HCID 58072731HCID 58072731, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound is synthesized according to general procedure GP3 starting from 2.82 g (11.0 mmol) 6-trifluoromethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 757 mg (5.5 mmol) K2CO3 in 25 mL MeOH. The product is purified by chromatography on silica gel using a cyclohexane/ethyl acetate gradient. Yield: 0.9 g (44%).

Workup

  1. customThe product is purified by chromatography on silica gel using a cyclohexane/ethyl acetate gradient

Sources & evidence

ORD record
ord-e52135c8582e4207a4a2e8cb2b386090
Source dataset
uspto-grants-2014_01
Patent number
US08633183B2

Reaction notes

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