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HRID471409

反应详情

EQUATION

反应方程式

HRID 471409 的结构方程式

REACTANTS

反应物

2
反应SMILES：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

反应SMILES：CCc1nc(N)ccc1C#C[Si](C)(C)C
HCID58072900

未命名化合物

PRODUCTS

产物

1
反应SMILES：C#Cc1ccc(N)nc1CC
HCID45078943

6-Ethyl-5-ethynylpyridin-2-amine

C9H10N2

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

The title compound is synthesized according to general procedure GP3 starting from 12.23 g (56 mmol) 6-ethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 3.87 g (28 mmol) K2CO3 in 120 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 4.5 g (85%).

WORKUP

后处理

  1. customThe product is purified by chromatography on silica gel using a DCM/MeOH gradient