反应详情

(1S,2S)-2-(4-tert-Butoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester (10.5 g, 35.62 mmol) is dissolved in trifluoroacetic acid (15 mL, 195.6 mmol) and stirred for 5 minutes. The mixture is concentrated under vacuum, then reevaporated five times from dichloromethane. The residue is dissolved in boiling cyclohexane (20 mL) and then allowed to cool. The cyclohexane layer is decanted off and the operation repeated. The residue is dried under vacuum to give the title compound (yield 6.51 g).

1. concentrationThe mixture is concentrated under vacuum
2. customreevaporated five times from dichloromethane
3. dissolutionThe residue is dissolved
4. temperatureto cool
5. customThe cyclohexane layer is decanted off
6. customThe residue is dried under vacuum