反应详情

温度

120 °C

4-Bromo-5-methoxy-indane-1-one (10 g, 41.48 mmol) and sodium methane-thiolate (12.68 g, 180.94 mmol) are dissolved in 25 mL of N,N-dimethylformamide and the reaction mixture is stirred at 120° C. for 3 h. The reaction mixture is concentrated under vacuum, 40 mL of a 2 M solution of hydrochloric acid is added and the reaction mixture is extracted with 300 mL of ethyl acetate. The organic phase is collected, dried over sodium sulfate and concentrated under vacuum. The crude product obtained (9 g) is used in the next step without any further treatment.

1. concentrationThe reaction mixture is concentrated under vacuum, 40 mL of a 2 M solution of hydrochloric acid
2. additionis added
3. extractionthe reaction mixture is extracted with 300 mL of ethyl acetate
4. customThe organic phase is collected
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under vacuum