4-Nitro-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide → 4-amino-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide

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Reaction Steps

4-Nitro-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide (1.2 g, 4.51 mmol) is suspended in methanol (10 mL) and hydrogenated at 3 bar for 3 hours using 10% palladium on activated carbon (120 mg) as the catalyst. The mixture is filtered through celite and the solvent removed under vacuum to give the title compound (Yield 900 mg).

Provenance & Evidence