反应详情

温度

85 °C

3-(2-Bromo-3-trifluoromethyl-phenyl)-propionic acid (3.0 g, 10.1 mmol) is suspended in trifluoromethanesulfonic acid (30 mL)) under argon and heated at 85° C. for 4 hours. The mixture is added dropwise to iced water and then extracted with ethyl acetate. The organic extract is washed with saturated sodium bicarbonate solution, dried and concentrated under vacuum. The residue is purified by flash chromatography (Eluent 0-5% EtOAc in cyclohexane) to give the title compound.

1. extractionextracted with ethyl acetate
2. extractionThe organic extract
3. washis washed with saturated sodium bicarbonate solution
4. customdried
5. concentrationconcentrated under vacuum
6. customThe residue is purified by flash chromatography (Eluent 0-5% EtOAc in cyclohexane)