Ethyl Bromide → 2-Nitro-6-ethoxybenzonitrile

HRID 471587Notes

Reaction equation

[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:3]=1[C:4]#[N:5].[CH2:13](Br)[CH3:14]>>[N+:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:2]([O:1][CH2:13][CH3:14])[C:3]=1[C:4]#[N:5])([O-:12])=[O:11]

Participants

Reactant 2

HCID 6332Ethyl Bromide

HCID 125032052-Hydroxy-6-nitrobenzonitrile

Product 1

HCID 247777792-Nitro-6-ethoxybenzonitrileYield 50%

Procedure

Prepared in a similar manner as Example 115c from 2-hydroxy-6-nitrobenzonitrile (Example 115d) and ethyl bromide to provide 2-nitro-6-ethoxybenzonitrile (192 mg, 50%).

Sources & evidence

ORD record: ord-b98a7f8a24654c8c870aceeb5c7fffdc
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08633186B2

Reaction notes

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