Hydrochloric Acid → HCID 66747036, compound

HRID 471678Notes

Reaction equation

HRID 471678 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[C:16]=1[C:24]#[N:25])=O)(C)(C)C.[ClH:26]>>[Cl-:26].[C:24]([C:16]1[C:17]([N+:21]([O-:23])=[O:22])=[CH:18][CH:19]=[CH:20][C:15]=1[O:14][CH2:13][C@@H:9]1[CH2:10][CH2:11][CH2:12][NH2+:8]1)#[N:25]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 66747294HCID 66747294, compound

Product 1

HCID 66747036HCID 66747036, compoundYield 81%

Procedure

Prepared as in Example 166 from (S)-tert-butyl-2-((2-cyano-3-nitrophenoxy)methyl)pyrrolidine-1-carboxylate (Example 209c) in 81% yield as an off-white solid. MS 248 (MH+-HCl).

Sources & evidence

ORD record
ord-4acfa44fe6194c84bddd90e07bb84ee5
Source dataset
uspto-grants-2014_01
Patent number
US08633186B2

Reaction notes

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