HCID 67108470, compound → HCID 58237245, compound

HRID 471888Notes

Reaction equation

HRID 471888 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:18][CH2:17][C:16]3([CH2:23][CH2:22][CH2:21][CH:20]([NH:24]C(OCC4C=CC=CC=4)=O)[CH2:19]3)[C:15]2=[O:35])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:18][CH2:17][C:16]3([CH2:23][CH2:22][CH2:21][CH:20]([NH2:24])[CH2:19]3)[C:15]2=[O:35])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 67108470HCID 67108470, compound

Product 1

HCID 58237245HCID 58237245, compoundYield 77.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(7-Benzyloxycarbonylamino-1-oxo-2-aza-spiro[4.5]dec-2-yl)-piperidine-1-carboxylic acid tert-butyl ester (0.75 g, 1.54 mmol) in methanol (50.0 mL) was shaken under hydrogenated at 50 psi and rt for 2.5 hrs. The catalyst was filtered off, and the filtrate was concentrated to afford 0.42 g (77%) of the title compound. LC-MS (method C): RT: 0.94 min; ESI-MS m/z: 352 (M+H)+. It was used in the next step without further purification.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-5c466e319a534f7faa48936bcbe0767f
Source dataset
uspto-grants-2014_01
Patent number
US08633190B2

Reaction notes

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