Guanidine → 4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine

HRID 47206Notes

Reaction equation

HRID 47206 reaction equation
[CH3:1][C:2]1[N:6]=[C:5]([CH3:7])[S:4][C:3]=1/[CH:8]=[CH:9]/[C:10](N(C)C)=O.[NH2:15][C:16]([NH2:18])=[NH:17]>>[CH3:7][C:5]1[S:4][C:3]([C:8]2[CH:9]=[CH:10][N:15]=[C:16]([NH2:18])[N:17]=2)=[C:2]([CH3:1])[N:6]=1

Participants

3

Reactant 2

HCID 3520GuanidineHCID 916216443-Dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone

Product 1

HCID 4479564-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine

Procedure

This compound was prepared by heating equimolar amounts of 3-dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone and guanidine in refluxing 2-methoxethanol. 1H-NMR (300 MHz, CDCl3) δ2.67 (s, 3H, CH3), 2.68 (s, 3H, CH3), 5.14 (br, 2H, NH2), 6.83 (d, 1H, J=5.3 Hz, pyrimidinyl-H), 8.30 (d, 1H, J=5.3 Hz, pyrimidinyl-H).

Workup

  1. customThis compound was prepared
  2. temperaturein refluxing 2-methoxethanol

Sources & evidence

ORD record
ord-8c657b8e0a70442da4fd35d32f80cf70
Source dataset
uspto-grants-2004_03
Patent number
US06699854B2

Reaction notes

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