1-(4-Bromophenyl)piperidine → HCID 49838267, compound

HRID 472270Notes

Reaction equation

HRID 472270 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]3[N:13]([N:17]=[C:18]([NH2:20])[N:19]=3)[CH:14]=[CH:15][CH:16]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].Br[C:22]1[CH:27]=[CH:26][C:25]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[CH:24][CH:23]=1>>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]3[N:13]([N:17]=[C:18]([NH:20][C:22]4[CH:23]=[CH:24][C:25]([N:28]5[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]5)=[CH:26][CH:27]=4)[N:19]=3)[CH:14]=[CH:15][CH:16]=2)=[CH:7][CH:6]=1)(=[O:3])=[O:4]

Participants

3

Reactant 2

HCID 70164601-(4-Bromophenyl)piperidineHCID 575023768-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Product 1

HCID 49838267HCID 49838267, compound

Procedure

[8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(4-piperidin-1-yl-phenyl)-amine was prepared from 8-(4-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (100.0 mg, 0.3468 mmol) and 1-(4-bromo-phenyl)-piperidine (110.0 mg, 0.4581 mmol) in a manner analogous to Step 2d. The title compound was isolated as a yellow solid (0.039 g, 25%). MP=229-234° C. 1H NMR (400 MHz, CDCl3, δ, ppm):

Sources & evidence

ORD record
ord-d37639f4c1b744f89ba72f50194acce9
Source dataset
uspto-grants-2014_01
Patent number
US08633173B2

Reaction notes

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