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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 472360Generated: October 26, 2026

Ethyl isothiocyanatoformate → 8-Bromo-6-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

https://huagongshe.com/reaction/472360

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl isothiocyanatoformateHCID 85320—
ReactantHydroxyamine hydrochlorideHCID 443297—
Reactant3-Bromo-5-(trifluoromethyl)pyridin-2-amineHCID 13064155—
Product8-Bromo-6-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amineHCID 67481469—

Reaction Steps

8-Bromo-6-trifluoromethyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine was prepared from 3-bromo-5-trifluoromethyl-pyridin-2-ylamine, ethoxycarbonylisothiocyanate, and hydroxylamine hydrochloride in a manner analogous to Steps 2a-b. 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.24 (s, 1H), 8.08 (s, 1H), 6.62 (bs, 2H). MS=282.9 (MH)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08633173B2
Source datasetuspto-grants-2014_01
ORD IDord-994dd7d9b7fe421f9f74733c9fd06c65
Source noteuspto-grants-2014_01