(+-)-2-(Aminomethyl)-1-N-Boc-pyrrolidine → HCID 67479012, compound

HRID 472450Notes

Reaction equation

HRID 472450 reaction equation
Br[C:2]1[C:3]2[N:4]([N:8]=[C:9]([Cl:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[C:12]([O:16][C:17]([N:19]1[CH2:23][CH2:22][CH2:21][CH:20]1[CH2:24][NH2:25])=[O:18])([CH3:15])([CH3:14])[CH3:13]>>[C:12]([O:16][C:17]([N:19]1[CH2:23][CH2:22][CH2:21][CH:20]1[CH2:24][NH:25][C:2]1[C:3]2[N:4]([N:8]=[C:9]([Cl:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1)=[O:18])([CH3:15])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 2756484(+-)-2-(Aminomethyl)-1-N-Boc-pyrrolidineHCID 674813708-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 67479012HCID 67479012, compound

Procedure

2-[(2-Chloro-[1,2,4]triazolo[1,5-a]pyridin-8-ylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester was prepared from 8-bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine (500.0 mg, 2.151 mmol) and 2-aminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (475.0 mg, 2.372 mmol) in a manner analogous to Example 2d. Product isolated as a yellow viscous oil (0.411 g, 54%). MS=374, 376 (MH)+.

Sources & evidence

ORD record
ord-a1e5a654ba774e1fbbe7462f2a1ff385
Source dataset
uspto-grants-2014_01
Patent number
US08633173B2

Reaction notes

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