2-chloro-N,N-dimethylacetamide → HCID 59612525, compound

HRID 472599Notes

Reaction equation

HRID 472599 reaction equation
[F:1][CH:2]([F:33])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]3[N:11]([N:15]=[C:16]([NH:18][C:19]4[CH:24]=[CH:23][C:22]([CH:25]5[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]5)=[CH:21][CH:20]=4)[N:17]=3)[CH:12]=[CH:13][CH:14]=2)=[C:5]([O:31][CH3:32])[CH:4]=1.Cl[CH2:35][C:36]([N:38]([CH3:40])[CH3:39])=[O:37]>>[F:33][CH:2]([F:1])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]3[N:11]([N:15]=[C:16]([NH:18][C:19]4[CH:20]=[CH:21][C:22]([CH:25]5[CH2:26][CH2:27][N:28]([CH2:35][C:36]([N:38]([CH3:40])[CH3:39])=[O:37])[CH2:29][CH2:30]5)=[CH:23][CH:24]=4)[N:17]=3)[CH:12]=[CH:13][CH:14]=2)=[C:5]([O:31][CH3:32])[CH:4]=1

Participants

3

Reactant 2

HCID 758862-chloro-N,N-dimethylacetamideHCID 59612463HCID 59612463, compound

Product 1

HCID 59612525HCID 59612525, compound

Procedure

2-(4-{4-[8-(4-difluoromethyl-2-methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperidin-1-yl)-N,N-dimethyl-acetamide was prepared from [8-(4-difluoromethyl-2-methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-yl]-(4-piperidin-4-yl-phenyl)-amine (0.160 g, 0.356 mmol) and 2-chloro-N,N-dimethyl-acetamide (0.055 mL, 0.534 mmol) in a manner analogous to Example 313 to give product (0.035 g, 18%).

Sources & evidence

ORD record
ord-61673a4e0204407a8a1e091ec3e722a7
Source dataset
uspto-grants-2014_01
Patent number
US08633173B2

Reaction notes

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