反应详情

Furo[2,3-c]isoquinolin-5(4H)-one (55 mg, 0.27 mmol) was dissolved in a mixture of dry dimethylformamide (1 ml) and dry acetonitrile (2 ml) and treated with N,N-dimethyl(methylene)ammonium chloride (1 mmol) prepared according to known procedure (Kinast G. et al. Angew. Chem. Int. Ed. Engl. 1976, 15(4), 239-240; Bohme H. et al. Chem. Ber. 1960, 93, 1305). The reaction mixture was refluxed overnight, and the resulting precipitate was filtered and washed with dry diethyl ether to give the title compound. Yield: 65%.

1. customprepared
2. temperatureThe reaction mixture was refluxed overnight
3. filtrationthe resulting precipitate was filtered
4. washwashed with dry diethyl ether