Trifluoroacetic acid → HCID 59317679, compound

Participants

Reaction Steps

A round bottomed flask is charged with {1-[(2,6-Dichloro-pyridin-4-ylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-acetic acid tert-butyl ester (50.9 mg, 0.106 mmol) is treated with DCM (1.5 ml) and TFA (1.5 ml). The reaction mixture is stirred at RT for 2 hours and then concentrated in vacuo. The residue is taken up in a minimal amount of DCM and concentrated in vacuo. This process is repeated twice with EtOAc, and twice with MeOH to give the title compound, [M+H]+ 422

Provenance & Evidence