Trifluoroacetic acid → HCID 59317679, compound

HRID 472733Notes

Reaction equation

HRID 472733 reaction equation
C([O:5][C:6](=[O:32])[CH2:7][N:8]1[C:17](=[O:18])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([CH2:19][C:20](=[O:30])[NH:21][C:22]2[CH:27]=[C:26]([Cl:28])[N:25]=[C:24]([Cl:29])[CH:23]=2)[C:9]1=[O:31])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:28][C:26]1[CH:27]=[C:22]([NH:21][C:20]([CH2:19][N:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:17](=[O:18])[N:8]([CH2:7][C:6]([OH:32])=[O:5])[C:9]2=[O:31])=[O:30])[CH:23]=[C:24]([Cl:29])[N:25]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59317726HCID 59317726, compound

Product 1

HCID 59317679HCID 59317679, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A round bottomed flask is charged with {1-[(2,6-Dichloro-pyridin-4-ylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-acetic acid tert-butyl ester (50.9 mg, 0.106 mmol) is treated with DCM (1.5 ml) and TFA (1.5 ml). The reaction mixture is stirred at RT for 2 hours and then concentrated in vacuo. The residue is taken up in a minimal amount of DCM and concentrated in vacuo. This process is repeated twice with EtOAc, and twice with MeOH to give the title compound, [M+H]+ 422

Workup

  1. concentrationconcentrated in vacuo
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-c7b84416ba58401db0707fb118ab96c1
Source dataset
uspto-grants-2014_01
Patent number
US08633211B2

Reaction notes

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