反应详情

An off-white suspension of {1-[(5-chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2-oxo-1,4-dihydro-2H-quinazolin-3-yl}-acetic acid methyl ester (Intermediate I) (400 mg, 0.893 mmol) in MeOH (10 ml) is treated with 5 M KOH (5 ml). The resulting white suspension is left to stir at RT overnight to give clear solution. The aqueous reaction mixture is acidified with dilute HCl (1 M) to pH 4 to give a thick white precipitate which is filtered, washed with water and vacuum dried to afford the title compound as pale yellow solid; [M+H]+ 434.

1. waitThe resulting white suspension is left
2. customto give clear solution
3. customto give a thick white precipitate which
4. filtrationis filtered
5. washwashed with water and vacuum
6. customdried