Lithium Hydroxide → HCID 54397381, Verbindung

HRID 472782Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 472782
[OH-].[Li+].[CH2:3]([C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[C:15]([C:19]([O:21]C)=[O:20])=[CH:14][CH:13]=[CH:12]2)[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]>>[CH2:3]([C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[C:15]([C:19]([OH:21])=[O:20])=[CH:14][CH:13]=[CH:12]2)[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Komponenten

3

Edukt 2

HCID 3939Lithium HydroxideHCID 66660876Methyl 6-hexyl-1-naphthoate

Produkt 1

HCID 54397381HCID 54397381, VerbindungAusbeute 97,3 %

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

Aqueous 1 N lithium hydroxide (3.6 mL, 3.6 mmol) was added to a solution of methyl 6-hexyl-1-naphthoate (198 mg, 0.73 mmol) THF (16 mL) in a scintillation vial. The vial was sealed and heated at 40° C. After 24 h, the reaction mixture was allowed to cool and the volatiles were evaporated under a stream of nitrogen. The residue was diluted with water (3 mL), acidified with 1 N aqueous HCl (5 mL) and extracted with EtOAc. (2×50 mL). The combined organic phase was dried (Na2SO4), filtered and concentrated in vacuo to afford 182 mg (97%) of 6-hexyl-1-naphthoic acid, which was used without hither purification.

Aufarbeitung

  1. customThe vial was sealed
  2. temperatureto cool
  3. customthe volatiles were evaporated under a stream of nitrogen
  4. additionThe residue was diluted with water (3 mL)
  5. extractionextracted with EtOAc
  6. dry with materialThe combined organic phase was dried (Na2SO4)
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-07f1aa4c9a37416691903d71441feb79
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08633220B2

Notizen zur Reaktion

Wird geladen…