反应详情

温度

40 °C

Aqueous 1 N lithium hydroxide (3.6 mL, 3.6 mmol) was added to a solution of methyl 6-hexyl-1-naphthoate (198 mg, 0.73 mmol) THF (16 mL) in a scintillation vial. The vial was sealed and heated at 40° C. After 24 h, the reaction mixture was allowed to cool and the volatiles were evaporated under a stream of nitrogen. The residue was diluted with water (3 mL), acidified with 1 N aqueous HCl (5 mL) and extracted with EtOAc. (2×50 mL). The combined organic phase was dried (Na2SO4), filtered and concentrated in vacuo to afford 182 mg (97%) of 6-hexyl-1-naphthoic acid, which was used without hither purification.

1. customThe vial was sealed
2. temperatureto cool
3. customthe volatiles were evaporated under a stream of nitrogen
4. additionThe residue was diluted with water (3 mL)
5. extractionextracted with EtOAc
6. dry with materialThe combined organic phase was dried (Na2SO4)
7. filtrationfiltered
8. concentrationconcentrated in vacuo