Perchloric Acid → HCID 66692913, compound

HRID 472819Notes

Reaction equation

HRID 472819 reaction equation
[OH:1][CH:2]([C:7]1[C:8]([CH3:29])=[N:9][C:10]2[N:11]([N:20]=[C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:22]=2)[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1)[C:3]([O:5][CH3:6])=[O:4].Cl(O)(=O)(=O)=O>C(OC(C)(C)C)(=O)C>[C:7]([O:1][CH:2]([C:7]1[C:8]([CH3:29])=[N:9][C:10]2[N:11]([N:20]=[C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:22]=2)[C:12]=1[C:13]1[CH:14]=[CH:15][C:16]([CH3:19])=[CH:17][CH:18]=1)[C:3]([O:5][CH3:6])=[O:4])([CH3:8])([CH3:12])[CH3:2]

Participants

4

Reactant 2

HCID 24247Perchloric AcidHCID 66693001HCID 66693001, compound

Product 1

HCID 66692913HCID 66692913, compound

Reagents, catalysts & solvents 1

HCID 10908tert-Butyl acetateSolvent

Procedure

To a solution of methyl 2-hydroxy-2-(5-methyl-2-phenyl-7-p-tolylpyrazolo[1,5-a]pyrimidin-6-yl)acetate (6.20 mg, 0.016 mmol) in tert-butyl acetate (0.3 mL) at room temperature was added perchloric acid (0.008 mL, 0.128 mmol). The reaction mixture was stirred for 2 h at room temperature. The reaction mixture was quenched with water and diluted with ethyl acetate. The organic phase was washed with saturated NaHCO3 and dried over sodium sulfate. The solvent was evaporated to give the title compound. The crude product was used directly for next step.

Workup

  1. customThe reaction mixture was quenched with water
  2. additiondiluted with ethyl acetate
  3. washThe organic phase was washed with saturated NaHCO3
  4. dry with materialdried over sodium sulfate
  5. customThe solvent was evaporated

Sources & evidence

ORD record
ord-b3030d1dfe25451aa21fdd33e8e17ecf
Source dataset
uspto-grants-2014_01
Patent number
US08633200B2

Reaction notes

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