HCID 66693624, compound → HCID 86670267, compound

HRID 472822Notes

Reaction equation

HRID 472822 reaction equation
[CH3:1][C:2]1[C:7]([CH2:8][OH:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)[N:5]2[N:17]=[CH:18][CH:19]=[C:4]2[N:3]=1.C1C=C[NH+]=CC=1.[O-][Cr](Cl)(=O)=O>C(Cl)Cl>[CH3:1][C:2]1[C:7]([CH:8]=[O:9])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([CH3:16])=[CH:14][CH:15]=2)[N:5]2[N:17]=[CH:18][CH:19]=[C:4]2[N:3]=1

Participants

4

Reactant 2

HCID 66693624HCID 66693624, compoundHCID 178418287HCID 178418287, compound

Product 1

HCID 86670267HCID 86670267, compoundYield 71.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of (5-methyl-7-p-tolylpyrazolo[1,5-a]pyrimidin-6-yl)methanol (300 mg, 1.18 mmol) in CH2Cl2 (24 mL) was added PCC (383 mg, 1.78 mmol). The reaction mixture was stirred at room temperature for 16 h. The solvent was evaporated and the residue was purified by silica gel chromatography to give the title compound (212 mg, 71.2%).

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-ba8509c9311142b2838c71cbb3987c65
Source dataset
uspto-grants-2014_01
Patent number
US08633200B2

Reaction notes

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