HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Methoxy-3-(trifluoromethyl)benzylamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | N-[4-methoxy-3-(trifluoromethyl)benzyl]formamide | HCID 22744421 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Methoxy-3-(trifluoromethyl)benzylamine hydrochloride | HCID 22744537 | — |
Reaction Steps
3.8 g of N-[4-methoxy-3-(trifluoromethyl)benzyl]formamide was dissolved in 20 ml ethanol, 2 ml conc. hydrochloric acid was added thereto, and the mixture was heated under reflux for 3 hr. After cooling, diethyl ether was added thereto, and the resulting crystals were collected by filtration to give 2.5 g of 4-methoxy-3-(trifluoromethyl)benzylamine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699870B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-6d6291f394684e2fb7328e9ec108a50f |
| Source note | uspto-grants-2004_03 |