Hydrochloric Acid → 4-Methoxy-3-(trifluoromethyl)benzylamine hydrochloride

HRID 47296Notes

Reaction equation

HRID 47296 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([CH2:7][NH:8]C=O)=[CH:5][C:4]=1[C:13]([F:16])([F:15])[F:14].[ClH:17].C(OCC)C>C(O)C>[ClH:17].[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([CH2:7][NH2:8])=[CH:5][C:4]=1[C:13]([F:14])([F:15])[F:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 22744421N-[4-methoxy-3-(trifluoromethyl)benzyl]formamide

Product 1

HCID 227445374-Methoxy-3-(trifluoromethyl)benzylamine hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.8 g of N-[4-methoxy-3-(trifluoromethyl)benzyl]formamide was dissolved in 20 ml ethanol, 2 ml conc. hydrochloric acid was added thereto, and the mixture was heated under reflux for 3 hr. After cooling, diethyl ether was added thereto, and the resulting crystals were collected by filtration to give 2.5 g of 4-methoxy-3-(trifluoromethyl)benzylamine hydrochloride.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hr
  3. temperatureAfter cooling
  4. filtrationthe resulting crystals were collected by filtration

Sources & evidence

ORD record
ord-6d6291f394684e2fb7328e9ec108a50f
Source dataset
uspto-grants-2004_03
Patent number
US06699870B2

Reaction notes

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