4-Methyloxybenzyl chloride → HCID 519849, compound

HRID 47297Notes

Reaction equation

HRID 47297 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Cl)=[CH:5][CH:4]=1.[K].[C:12]1(=[O:22])[NH:16][C:15](=[O:17])[C:14]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:13]12>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][N:16]2[C:15](=[O:17])[C:14]3=[CH:18][CH:19]=[CH:20][CH:21]=[C:13]3[C:12]2=[O:22])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 699934-Methyloxybenzyl chlorideHCID 24194345Phthalimide potassium salt

Product 1

HCID 519849HCID 519849, compoundYield 90.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 20 g 4-methoxybenzyl chloride, 26 g phthalimide potassium, and 100 ml dimethylformamide was stirred at 50° C. for 5 hr. After cooling, the reaction solution was poured into ice water and the resulting precipitates were collected by filtration. These were washed with water and dried to give 31 g of N-(4-methoxybenzyl)phthalimide.

Workup

  1. temperatureAfter cooling
  2. customthe resulting precipitates
  3. filtrationwere collected by filtration
  4. washThese were washed with water
  5. customdried

Sources & evidence

ORD record
ord-e3c8d2cecf1b4acbbfd6375d85c3135c
Source dataset
uspto-grants-2004_03
Patent number
US06699870B2

Reaction notes

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