HRID473079
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 60 °C
PROCEDURE
实验过程
To a solution of (S)-N-(5-(3-(chloromethyl)-5-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-2-yl)propane-2-sulfonamide (0.090 mmol, 40 mg) in DMF (1 mL) was added dimethylamine (2M solution, 0.224 mmol, 0.112 mL). The whole was heated to 60° C. for 2 h before the reaction mixture was purified directly by prep HPLC to give the title compound. (21.2 mg, 52%). MS (ESI): m/z [M+H]+ 455.2
WORKUP
后处理
- customwas purified directly by prep HPLC