反应详情

温度

0 °C

To (S)-methyl 3-((2-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)benzoate (2.90 mmol, 1.4 g) at 0° C. in THF (29.0 mL) under an argon atmosphere was added Lithium aluminium hydride in THF (2.90 mmol, 2.90 mL) dropwise. The reaction was left to stir for 1.5 hrs at 0° C. The reaction was quenched with MeOH before the addition of 5N HCl (aq) to adjust the pH to 3. The reaction mix was diluted with DCM before washing with water (×1) followed by brine (×1). The DCM layer was dried over MgSO4 before removing the solvent in vacuo to give the product as a clear glassy solid (1.34 g, 102%). MS (ESI): m/z [M+H]+ 456.1

1. waitThe reaction was left
2. customThe reaction was quenched with MeOH before the addition of 5N HCl (aq)
3. additionThe reaction mix
4. additionwas diluted with DCM
5. washbefore washing with water (×1)
6. dry with materialThe DCM layer was dried over MgSO4
7. custombefore removing the solvent in vacuo