反应详情

Sodium 2-(5-fluoropyridin-2-yl)acetate is treated with 1-1.5 equiv of Br2 in the presence of phosphorus tribromide under standard Hell-Volhard-Zelinskii reaction conditions (J. March “Advanced Organic Chemistry” 3rd Edition, 1985, p. 531 and references therein) to afford 2-bromo-2-(5-fluoropyridin-2-yl)acetic acid.