HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → HCID 86662700, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | HCID 66609994 | HCID 66609994 | — |
| Product | HCID 86662700 | HCID 86662700 | — |
Reaction Steps
Sodium 2-(5-fluoropyridin-2-yl)acetate is treated with 1-1.5 equiv of Br2 in the presence of phosphorus tribromide under standard Hell-Volhard-Zelinskii reaction conditions (J. March “Advanced Organic Chemistry” 3rd Edition, 1985, p. 531 and references therein) to afford 2-bromo-2-(5-fluoropyridin-2-yl)acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08633207B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-a3a5e3e59d344f90935b5221889700e5 |
| Source note | uspto-grants-2014_01 |