Water → Ilorasertib

HRID 473292Notes

Reaction equation

HRID 473292 reaction equation
C([C@@H]([C@H](C(O)=O)O)O)(O)=O.[NH2:11][C:12]1[C:17]2[C:18]([C:21]3[CH:26]=[CH:25][C:24]([NH:27][C:28]([NH:30][C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([F:37])[CH:32]=4)=[O:29])=[CH:23][CH:22]=3)=[CH:19][S:20][C:16]=2[C:15]([C:38]2[CH:39]=[N:40][N:41]([CH2:43][CH2:44][OH:45])[CH:42]=2)=[CH:14][N:13]=1.O>O1CCCC1>[NH2:11][C:12]1[C:17]2[C:18]([C:21]3[CH:22]=[CH:23][C:24]([NH:27][C:28]([NH:30][C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([F:37])[CH:32]=4)=[O:29])=[CH:25][CH:26]=3)=[CH:19][S:20][C:16]=2[C:15]([C:38]2[CH:39]=[N:40][N:41]([CH2:43][CH2:44][OH:45])[CH:42]=2)=[CH:14][N:13]=1

Participants

4

Reactant 2

HCID 962WaterHCID 54759635HCID 54759635, compound

Product 1

HCID 46207586Ilorasertib

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

There is further provided a process for preparing N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea L-tartrate in a solid crystalline form, wherein the crystalline form is Form II comprising: a) providing a mixture comprising (i) N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea L-bitartrate solid, water, and tetrahydrofuran; b) causing N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea L-tartrate crystalline Form II to exist in the mixture.

Workup

  1. customThere is further provided a process

Sources & evidence

ORD record
ord-087f3c9726674d21acfb07fc848e2dce
Source dataset
uspto-grants-2014_01
Patent number
US08633317B2

Reaction notes

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