Hydrochloric Acid → HCID 54759636, compound

Participants

Reaction Steps

N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea free base solid (89 mg) was suspended in ethanol (2.5 mL) at 40° C. with magnetic stirring. Hydrochloric acid (380 μL, 1 N) was diluted with water (620 μL). Hydrochloric acid solution was slowly added to A-968660 free base suspension at 40° C. with magnetic stirring. Crystallization was observed shortly after the complete addition of the HCl solution. Solid was collected by centrifuge filtration.

Provenance & Evidence