反应详情

N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea free base solid (89 mg) was suspended in ethanol (2.5 mL) at 40° C. with magnetic stirring. Hydrochloric acid (380 μL, 1 N) was diluted with water (620 μL). Hydrochloric acid solution was slowly added to A-968660 free base suspension at 40° C. with magnetic stirring. Crystallization was observed shortly after the complete addition of the HCl solution. Solid was collected by centrifuge filtration.

1. customCrystallization
2. additionafter the complete addition of the HCl solution
3. filtrationSolid was collected by centrifuge filtration