Sulfuric Acid → HCID 54759820, compound

HRID 473307Notes

Reaction equation

HRID 473307 reaction equation
[NH2:1][C:2]1[C:7]2[C:8]([C:11]3[CH:16]=[CH:15][C:14]([NH:17][C:18]([NH:20][C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[CH:22]=4)=[O:19])=[CH:13][CH:12]=3)=[CH:9][S:10][C:6]=2[C:5]([C:28]2[CH:29]=[N:30][N:31]([CH2:33][CH2:34][OH:35])[CH:32]=2)=[CH:4][N:3]=1.[S:36](=[O:40])(=[O:39])([OH:38])[OH:37]>CC(O)C>[S:36]([OH:40])([OH:39])(=[O:38])=[O:37].[NH2:1][C:2]1[C:7]2[C:8]([C:11]3[CH:12]=[CH:13][C:14]([NH:17][C:18]([NH:20][C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[CH:22]=4)=[O:19])=[CH:15][CH:16]=3)=[CH:9][S:10][C:6]=2[C:5]([C:28]2[CH:29]=[N:30][N:31]([CH2:33][CH2:34][OH:35])[CH:32]=2)=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 46207586Ilorasertib

Product 1

HCID 54759820HCID 54759820, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea free base solid (15 mg) was suspended in 2-propanol (150 μL). Sulfuric acid solution (98%, 4 μL) was added to the suspension. The suspension was stirred at ambient temperatures for 10 days. Solid was collected by centrifuge filtration.

Workup

  1. filtrationSolid was collected by centrifuge filtration

Sources & evidence

ORD record
ord-266baa8288ff491b8ffc7efe0ccd993d
Source dataset
uspto-grants-2014_01
Patent number
US08633317B2

Reaction notes

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