反应详情

11.0 g of 1-benzyl-4-piperidinecarbonitrile was dissolved in 100 ml 1,2-dichloroethane, 7.1 ml 1-chloroethyl chloroformate was added thereto under ice-cooling. The mixture was stirred at room temperature for 15 min, and then heated under reflux for 1 hr and 20 min. After evaporating, 50 ml methanol was added thereto and it was heated under reflux for 1 hr. The reaction solution was evaporated, and the crystalline residue was washed with ethyl acetate and collected by filtration to give 8.0 g of 4-piperidinecarbonitrile hydrochloride as white crystals.

1. temperatureunder ice-cooling
2. temperatureheated
3. temperatureunder reflux for 1 hr and 20 min
4. customAfter evaporating
5. addition50 ml methanol was added
6. temperatureit was heated
7. temperatureunder reflux for 1 hr
8. customThe reaction solution was evaporated
9. washthe crystalline residue was washed with ethyl acetate
10. filtrationcollected by filtration