反应详情

温度

25 °C

4-Dimethylaminopyridine (0.35 wt), (+)-menthol (0.95 wt) and ethyl 2-oxo-3-piperidinecarboxylate (1 wt) are dissolved/suspended in toluene (10 vol). The mixture is heated to reflux and stirred for seven days with periodic distillation of solvent and replenishment with fresh toluene. The reaction mixture is cooled to 25° C. and washed with two portions of 5% w/w aqueous HCl (4 vol) and then water (4 vol). The organic phase is concentrated under reduced pressure to give the title compound as a colourless oil.

1. temperatureThe mixture is heated
2. temperatureto reflux
3. washwashed with two portions of 5% w/w aqueous HCl (4 vol)
4. concentrationThe organic phase is concentrated under reduced pressure