Hydrazine → HCID 58318606, compound

HRID 473413Notes

Reaction equation

HRID 473413 reaction equation
[C:1]1([C:7]2[C:8]([CH:17]([N:19]3C(=O)C4C(=CC=CC=4)C3=O)[CH3:18])=[N:9][C:10]3[C:15]([CH:16]=2)=[N:14][CH:13]=[CH:12][CH:11]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.NN>CCO>[C:1]1([C:7]2[C:8]([CH:17]([NH2:19])[CH3:18])=[N:9][C:10]3[C:15]([CH:16]=2)=[N:14][CH:13]=[CH:12][CH:11]=3)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 58318609HCID 58318609, compound

Product 1

HCID 58318606HCID 58318606, compoundYield 115.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(1-(3-Phenyl-1,5-naphthyridin-2-yl)ethyl)isoindoline-1,3-dione (120 mg, 0.32 mmol) was suspended in EtOH (2 mL) and treated with NH2NH2 (0.2 mL) at 70° C. for 30 min and worked up to give a colorless oil (92 mg, 96%). LC-MS (ESI) m/z 250 [M+H]+.

Sources & evidence

ORD record
ord-d22561f908a640829703ed8fd840ccc3
Source dataset
uspto-grants-2014_01
Patent number
US08633313B2

Reaction notes

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