Ethyl Acetate → 3-Oxo-2-oxa-8-azaspiro[4.5]decane hydrochloride

HRID 47343Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 47343
[O:1]=[C:2]1[CH2:6][C:5]2([CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[CH2:4][O:3]1.[ClH:19].C(OCC)(=O)C.C(OCC)(=O)C>CO>[ClH:19].[O:1]=[C:2]1[CH2:6][C:5]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:4][O:3]1

Komponenten

5

Edukt 3

HCID 8857Ethyl AcetateHCID 21866389Hydrogen chloride-ethyl acetateHCID 22744536Tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate

Produkt 1

HCID 219553133-Oxo-2-oxa-8-azaspiro[4.5]decane hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

1.16 g of tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate was dissolved in 2.3 ml methanol, 4.6 ml of 4 N hydrochloric acid/ethyl acetate was added thereto, and the mixture was stirred at room temperature for 1 hr. 5 ml ethyl acetate was added thereto, and the resulting crystals were collected by filtration to give 700 mg of 3-oxo-2-oxa-8-azaspiro[4.5]decane hydrochloride.

Aufarbeitung

  1. filtrationthe resulting crystals were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-c90b274ab8f645e7a8d702384fae3f33
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699870B2

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