HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 3-Oxo-2-oxa-8-azaspiro[4.5]decane hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | Tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate | HCID 22744536 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Oxo-2-oxa-8-azaspiro[4.5]decane hydrochloride | HCID 21955313 | — |
Reaction Steps
1.16 g of tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate was dissolved in 2.3 ml methanol, 4.6 ml of 4 N hydrochloric acid/ethyl acetate was added thereto, and the mixture was stirred at room temperature for 1 hr. 5 ml ethyl acetate was added thereto, and the resulting crystals were collected by filtration to give 700 mg of 3-oxo-2-oxa-8-azaspiro[4.5]decane hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699870B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-c90b274ab8f645e7a8d702384fae3f33 |
| Source note | uspto-grants-2004_03 |