反应详情

For the synthesis of the title compound, 0.54 g (0.0020 mol) of 8-chloro-1-methoxy-10,11-dihydrodibenzo[a,d]cyclohepten-5-one, 1.08 g (0.010 mol) of phenylenediamine, 2 spatula tips of Pd(OAc)2, 0.14 g of phosphine ligand and 1.60 g (0.0166 mol) of NaOtert-Bu in 10 ml of toluene and 2 ml of tert-BuOH are reacted by method O. Purification is carried out by column chromatography (flash; SiO2; hexane 80%/ethyl acetate 20%). C22H20N2O2 (Mr=344.42)