Stannous chloride dihydrate → 3-(2-Amino-4-fluorophenylamino)-8-nitro-6H-dibenzo[b,e]oxepin-11-one

HRID 473489Notes

Reaction equation

HRID 473489 reaction equation
O.O.[Sn](Cl)Cl.[F:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]2[CH:15]=[CH:16][C:17]3[C:23](=[O:24])[C:22]4[CH:25]=[CH:26][C:27]([N+:29]([O-:31])=[O:30])=[CH:28][C:21]=4[CH2:20][O:19][C:18]=3[CH:32]=2)=[C:9]([N+:33]([O-])=O)[CH:8]=1>C(O)C>[NH2:33][C:9]1[CH:8]=[C:7]([F:6])[CH:12]=[CH:11][C:10]=1[NH:13][C:14]1[CH:15]=[CH:16][C:17]2[C:23](=[O:24])[C:22]3[CH:25]=[CH:26][C:27]([N+:29]([O-:31])=[O:30])=[CH:28][C:21]=3[CH2:20][O:19][C:18]=2[CH:32]=1

Participants

4

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 866648103-(4-Fluoro-2-nitrophenylamino)-8-nitro-6H-dibenzo[b,e]oxepin-11-one

Product 1

HCID 452799113-(2-Amino-4-fluorophenylamino)-8-nitro-6H-dibenzo[b,e]oxepin-11-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In accordance with general method Y, 0.60 g (2.66 mmol) of tin(II) chloride dihydrate is dissolved in 10 ml of ethanol, and 0.10 g (0.89 mmol) of (11) is added. Yield: 0.01 g (11.9%);

Sources & evidence

ORD record
ord-a989fd9a0b134c31b54c90189a4a0d31
Source dataset
uspto-grants-2014_01
Patent number
US08633312B2

Reaction notes

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