Stannous chloride dihydrate → 8-Amino-3-(2-amino-4-trifluoromethylphenylamino)-6H-dibenzo[b,e]oxepin-11-one

HRID 473495Notes

Reaction equation

HRID 473495 reaction equation
O.O.[Sn](Cl)Cl.[N+:6]([C:9]1[CH:38]=[CH:37][C:12]2[C:13](=[O:36])[C:14]3[CH:21]=[CH:20][C:19]([NH:22][C:23]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][C:24]=4[N+:33]([O-])=O)=[CH:18][C:15]=3[O:16][CH2:17][C:11]=2[CH:10]=1)([O-])=O>C(O)C>[NH2:6][C:9]1[CH:38]=[CH:37][C:12]2[C:13](=[O:36])[C:14]3[CH:21]=[CH:20][C:19]([NH:22][C:23]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:30])[F:31])=[CH:25][C:24]=4[NH2:33])=[CH:18][C:15]=3[O:16][CH2:17][C:11]=2[CH:10]=1

Participants

4

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 866648118-Nitro-3-(2-nitro-4-trifluoromethylphenylamino)-6H-dibenzo[b,e]oxepin-11-one

Product 1

HCID 452807458-Amino-3-(2-amino-4-trifluoromethylphenylamino)-6H-dibenzo[b,e]oxepin-11-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In accordance with general method Y, 0.30 g (1.32 mmol) of tin(II) chloride dihydrate is dissolved in 15 ml of ethanol, and 0.095 g (0.20 mmol) of (18) is added. Yield: 0.061 g (76.4%); melting point: 93.9° C.; C21H16F3N3O2 (Mr=399.38); LC 19.06 min

Workup

  1. customLC 19.06 min

Sources & evidence

ORD record
ord-1b324f2669c944cbb407a94d2b02ef34
Source dataset
uspto-grants-2014_01
Patent number
US08633312B2

Reaction notes

Loading…