Hydrogen Bromide → HCID 45279962, compound

HRID 473500Notes

Reaction equation

HRID 473500 reaction equation
[NH2:1][C:2]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:3]=1[NH:4][C:5]1[CH:22]=[CH:21][C:8]2[C:9](=[O:20])[C:10]3[CH:17]=[C:16]([O:18]C)[CH:15]=[CH:14][C:11]=3[CH2:12][CH2:13][C:7]=2[CH:6]=1.Br>C(O)(=O)C>[NH2:1][C:2]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:3]=1[NH:4][C:5]1[CH:22]=[CH:21][C:8]2[C:9](=[O:20])[C:10]3[CH:17]=[C:16]([OH:18])[CH:15]=[CH:14][C:11]=3[CH2:12][CH2:13][C:7]=2[CH:6]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 45280411HCID 45280411, compound

Product 1

HCID 45279962HCID 45279962, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

0.2 g (0.55 mmol) of 2-(2-amino-4-fluoroanilino)-7-methoxy-10,11-dihydrodibenzo[a,d]-cyclohepten-5-one is dissolved in 2 ml of glacial acetic acid, 2 ml of HBr (45%) are added and the mixture is refluxed for 6 h. The solution is hydrolyzed with 200 g of ice and the precipitate is filtered off. The product is obtained in the form of a white powder. C21H17FN2O2 (Mr=348.38)

Workup

  1. temperaturethe mixture is refluxed for 6 h
  2. filtrationthe precipitate is filtered off
  3. customThe product is obtained in the form of a white powder

Sources & evidence

ORD record
ord-4f682b11a53b49318f7e875a0baaccff
Source dataset
uspto-grants-2014_01
Patent number
US08633312B2

Reaction notes

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