Hydrogen Bromide → HCID 45279909, compound

HRID 473502Notes

Reaction equation

HRID 473502 reaction equation
[NH:1]([C:8]1[CH:25]=[CH:24][C:11]2[C:12](=[O:23])[C:13]3[CH:20]=[C:19]([O:21]C)[CH:18]=[CH:17][C:14]=3[CH2:15][CH2:16][C:10]=2[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br>C(O)(=O)C>[NH:1]([C:8]1[CH:25]=[CH:24][C:11]2[C:12](=[O:23])[C:13]3[CH:20]=[C:19]([OH:21])[CH:18]=[CH:17][C:14]=3[CH2:15][CH2:16][C:10]=2[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 45280466HCID 45280466, compound

Product 1

HCID 45279909HCID 45279909, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

0.2 g (0.61 mmol) of 2-anilino-7-methoxy-10,11-dihydrodibenzo[a,d]-cyclohepten-5-one is dissolved in 2 ml of glacial acetic acid, 2 ml of HBr (45%) are added and the mixture is refluxed for 6 h. The solution is hydrolyzed with 200 g of ice and the precipitate is filtered off. The product is obtained in the form of a white powder. C21H17NO2 (Mr=315.380)

Workup

  1. temperaturethe mixture is refluxed for 6 h
  2. filtrationthe precipitate is filtered off
  3. customThe product is obtained in the form of a white powder

Sources & evidence

ORD record
ord-c3d9d332f247473c834050612ea5af19
Source dataset
uspto-grants-2014_01
Patent number
US08633312B2

Reaction notes

Loading…