反应详情

In a three-necked flask equipped with a Dean Stark apparatus, a mixture of 5.1 g (20.3 mmol) of 2-fluoro-4-iodo-3-pyridinecarbaldehyde, 1.4 g (22.3 mmol) of ethane-1,2-diol, and 50 mg of para-toluenesulphonic acid in 100 ml of toluene is heated at reflux. When the theoretical amount of water has been collected, the reaction mixture is cooled to room temperature, washed with a saturated sodium hydrogen carbonate solution and dried over magnesium sulphate. The expected product is obtained by concentration.

1. customIn a three-necked flask equipped with a Dean Stark apparatus
2. temperatureis heated
3. temperatureat reflux
4. customWhen the theoretical amount of water has been collected
5. washwashed with a saturated sodium hydrogen carbonate solution
6. dry with materialdried over magnesium sulphate