HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 473712Generated: October 30, 2026
4-Aminophenol → 4-(5-Methylpyridin-2-ylamino)phenol
https://huagongshe.com/reaction/473712
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Chloro-5-methyl-pyridine | HCID 581393 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(5-Methylpyridin-2-ylamino)phenol | HCID 59373986 | — |
Reaction Steps
A mixture of 4-aminophenol (2 g, 18.33 mmol) and 2-chloro-5-methylpyridine (2.57 g, 20.16 mmol) was heated neat at 180° C. in 2 h. The reaction mixture was cooled, taken up in H2O, neutralized with saturated NaHCO3, extracted with DCM (3×). The extracts were dried over MgSO4, concentrated to give the dark purple solid. MS (ESI, pos. ion) m/z: 201.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637500B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-e3015e5419014714beac64afa1bf1bdc |
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| Source note | uspto-grants-2014_01 |
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