HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutylamine → HCID 59374131, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutylamine | HCID 6558 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 2-(4-(Pyridin-2-ylamino)phenoxy)nicotinic acid | HCID 59373922 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59374131 | HCID 59374131 | — |
Reaction Steps
HATU (178 mg, 0.469 mmol) was added to a mixture of 2-(4-(pyridin-2-ylamino)phenoxy)nicotinic acid (131 mg, 0.426 mmol) and diisopropylethylamine (148 μL, 0.853 mmol) in DMF (1 mL) and the mixture was stirred at rt for 10 min. Isobutylamine (63.5 μL, 0.639 mmol) was added and the mixture was stirred at rt for 1 h. The mixture was purified by chromatography on silica gel to deliver N-isobutyl-2-(4-(pyridin-2-ylamino)phenoxy)nicotinamide as a white solid. MS (ESI, pos. ion) m/z: 363.1 (M+1). IC50 (uM) 0.09344.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637500B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-49635fd0ac39482096960eb7ef2e0d88 |
| Source note | uspto-grants-2014_01 |