Hydrochloric Acid → 4-(Methylsulfanyl)piperidine hydrochloride

HRID 473803Notes

Reaction equation

HRID 473803 reaction equation
[CH3:1][S:2][CH:3]1[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]1.[ClH:16]>CO.O1CCOCC1>[ClH:16].[CH3:1][S:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11053478Tert-butyl 4-(methylthio)piperidine-1-carboxylate

Product 1

HCID 509989504-(Methylsulfanyl)piperidine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl 4-(methylthio)piperidine-1-carboxylate (63 mg, 0.27 mmol) in methanol (1 mL) and 4 N hydrogen chloride in dioxane (4 mL) was refluxed for 2 min and then concentrated and dried to provide 4-(methylthio)piperidine hydrochloride as a colorless oil.

Workup

  1. concentrationconcentrated
  2. customdried

Sources & evidence

ORD record
ord-bf18d89f947e418da75f772f78ba9115
Source dataset
uspto-grants-2014_01
Patent number
US08637499B2

Reaction notes

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